Atherosclerotic Coronary Plaque features in patients with Acute Coronary Syndrome and Chronic Obstructive Pulmonary Disease

Abstract Background Chronic obstructive pulmonary disease (COPD) is a common respiratory disorder characterized by airflow limitation, persistent symptoms and chronic lung inflammation. Previous studies reported robust relationship between COPD coronary artery (CAD). Local systemic inflammation, known to play role in atherosclerosis development, has been patients with COPD, proposed as one of the possible pathogenetic factors linking CAD. However, data on atherosclerotic pattern inflammation are lacking. Purpose To study characteristics plaques local using optical coherence tomography (OCT) presenting acute syndromes (ACS). Methods ACS undergoing intracoronary OCT imaging culprit vessel were retrospectively identified. Coronary plaque OCT-defined macrophage infiltration (MØI) assessed OCT. divided into 2 groups according presence or absence an established diagnosis features MØI both at site along compared two groups. Results Among 146 (mean age, 66,1±12,7 years, 109 males), 47 (32,2%) had COPD. Patients older, more frequently therapy angiotensin receptor blocker, lower hemoglobin, total cholesterol triglycerides levels, higher serum creatinine levels. The prevalence different mechanisms similar noCOPD (plaque rupture: 57,4% vs. 45,4%, erosion: 23,4% 32,3%, calcified plaque: 19,1% 22,2%, respectively, overall p=0,381). analysis microstructures showed that significantly (78,7% 54,4%, p=0,005), thin cap fibroatheroma (TCFA) (48,9% p=0,001), spotty calcium (68,1% 26,3%, p<0,001) calcifications (83,0% 66,7%, p=0,040) than patients. In multivariate logistic regression performed adjust for clinical features, was independently associated (OR: 4,726, CI: 1,599; 13,971, p=0,005) 2,193, 1,110; 4,332, p=0,024). Similarly, TCFA 5,737, 1,877; 17,540, p=0,002) 2,796, 1,408; 5,553, p=0,003). Conclusions vessel, independent predictor vulnerability vessel. Our results may suggest inflammatory milieu might enhance promoting CAD development vulnerability. Funding Acknowledgement Type funding sources: None.